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one, 7.2) ]. Threats of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant use of Promethazine with Codeine Oral Option with all cytochrome P450 2D6 inhibitors (eg., amiodarone, quinidine) may perhaps cause a rise in codeine plasma concentrations plus a lessen in active metabolite morphine plasma focus which could